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Magnesium is typically obtained by humans through their diet and can be found in high concentrations in a variety of dark green leafy vegetables and nuts. It is important to our bodies. However, are there any magnesium L-threonate side effects?

The compound magnesium L-threonate Magnesium L-Threonate, abbreviated as MgT, is a newer, more advanced form of the element magnesium. It can be found in a dictionary of chemical symbols.

The Massachusetts Institute of Technology (MIT) created this more bio-available version of the vitamin as a dietary supplement to increase a variety of cognitive functions, such as learning and short-term and long-term memory. Because this supplement is still relatively new, more in-depth research on this ingredient has not yet been conducted.

The following is a synopsis of what is now known about how this derivative of a basic mineral that is commonly supplemented could potentially have a major impact on cognitive ability.

The Impact of Magnesium L-Threonate on the Body

Magnesium L-Threonate Side Effects

Magnesium is already required by the body for the proper operation of a great many of its fundamental processes. Magnesium is normally found in amounts of 25 grams throughout the human body at any given moment.

It has an important role in the development of bones, as well as in improving the efficiency of nerve communication and the body’s ability to respond to stimuli. In addition to this, it raises energy throughout the central nervous system and stimulates the metabolism of glucose.

Recent research conducted at the Massachusetts Institute of Technology (MIT) and Tsinghua University in Beijing discovered that Magnesium L-Threonate greatly increased the activity and flexibility of synapses. This indicates that the connections between neurons have a greater propensity to develop and demonstrate behaviours consistent with healthy and effective communication.

This was notably true in the hippocampus, which is the part of the brain that is responsible for all memory functions. This action may be achieved in part by magnesium L-ability threonates to increase the volume of cerebrospinal fluid found in the brain.

The Advantages of Magnesium L-Threonate

Magnesium L-Threonate was found to produce synaptic activity in test subjects, which in turn led to significant improvements in several types of memory in those subjects. Memory recall was improved, most noticeably in older patients.

This suggests that MgT may have an effect that slows down the natural deterioration in memory that occurs with advancing age. When brain tissues get older, they become less flexible and less likely to generate new synapses. This makes it harder for new connections to form.

Memory loss and an inability to learn new information, in general, are both side effects of this process, which also prevent the formation of new neural connections. Researchers are keeping their fingers crossed that MgT will be able to solve this issue.

It has also been demonstrated that the chemical can alleviate persistent neuropathic pain. There is significant disagreement regarding whether or not these benefits are noticeably distinct from those that can be accomplished by taking the typical amount of magnesium sulfate recommended. Memory improvement is observed in response to both chemicals’ presence.

These benefits are in addition to the typical benefits that magnesium provides, which include improvements in bone strength and neuron function as well as general boosts in mental and physical energy through increases in glucose production.

Magnesium deficiency has also been associated with irregular heartbeat, which is a condition that can be improved with the judicious use of magnesium supplements. In conclusion, magnesium tablets are frequently taken by people who have trouble falling or staying asleep. The mineral is a good treatment for insomnia since it is a natural muscle relaxer and can also help to calm the brain before night.

Magnesium L-Threonate Dosage and Administration

Magnesium L-Threonate Side Effects

The Advantages of Taking Magnesium L-Threonate

It is generally agreed that the recommended magnesium dosages for adults are 400 milligrams (mg) per day for men and 300 milligrams (mg) per day for women.

The majority of commercial products on the market that includes magnesium L-threonate provide as much as two thousand milligrams per serving. It is essential to take into consideration the fact that this quantity will correspond to around 140 mg of magnesium element in a form that is easily absorbable.

The majority of people take magnesium supplements in a ratio of one magnesium supplement to three calcium pills. When magnesium is used as part of a program to boost cognitive performance, many people combine it with oxiracetam, which reduces magnesium’s antagonism to NMDA receptors. This combination is known as a “stack.” Synaptic plasticity could potentially be increased as a consequence of this action in the theoretical sense.

Magnesium L-Threonate Can Cause the Following Side Effects

  • “Headaches, tiredness, and an impression of increased blood flow to the head are the only negative reactions to magnesium l-threonate that have been described yet. In general, taking magnesium supplements might cause stomach distress, which is one of the negative effects. The majority of the types work as laxatives.”
  • Magnesium, in all of its forms, can cause major negative effects if taken in excessive amounts. For certain individuals, taking very high quantities of magnesium (more than 350 milligrams per day) might result in dangerously low blood pressure, an erratic pulse, and severe brain fog. An extreme overdose has the potential to be fatal.
  • Magnesium should be fully avoided by anyone who has problems with their kidneys or who is taking medicine that affects the kidneys. Increasing the amount of magnesium in the diet can put an excessive strain on the kidneys. People who have been diagnosed with heart issues such as heart block should also avoid the mineral because it is dangerous for them.

Because it is a relatively new version, there has not been much in-depth research conducted on the adverse effects of Magnesium L-Threonate; nonetheless, the contraindications for Magnesium Sulfate should be very comparable.

An Examination of Magnesium L-Threonate

The cognitive benefits of magnesium sulfate are well-known; nevertheless, it’s possible that magnesium L-threonate could be an even more effective way to get those benefits. Memory for the short term, memory for the long term, and overall learning ability were all increased in test subjects.

Although it is not recommended for people who have kidney or heart disorders, it is at least as safe and effective as a regular magnesium sulfate supplement, which is regularly used by people all over the world.

It seems that magnesium L-threonate has better absorption rates and cognitive effects that are more intense than standard formulations.

The majority of people who take magnesium supplements do so in conjunction with calcium or with oxiracetam, both of which are intended to enhance memory performance. As additional data is accumulated, the use of magnesium trioxide (MgT) may someday become the method of choice for getting one’s daily dose of this very common and vital mineral.


Magnesium L-Threonate, often known as MgT, is a formulation that combines magnesium with L-threonic acid to increase the bioavailability of magnesium. The human body uses magnesium as a co-factor in more than 300 different enzymatic activities, however, despite this, 57% of the population in the United States is magnesium deficient.

Mechanism: plays a role in the regulation of a variety of biochemical reactions, including protein synthesis, the function of muscles and nerves, the metabolism of energy, the growth of bone, the function of the cardiovascular system, the regulation of blood glucose, sleep, mood, and other reactions.

Dosage: 200 – 500 mg each day.

Side Effects: It is likely safe for oral use when administered in the recommended doses. A dose that is too high may result in a dry mouth, a drop in blood pressure, sleepiness, muscle weakness, sluggish reflexes, and changes in the rhythm of the heart.

Synergy: This supplement can interact with others that affect platelet aggregation, including calcium, vitamin D, boron, and zinc.